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Original Articles
- Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys
- Young Sim Choi, Han Byul Jang, Ju Yeon Park, Hye-Ja Lee, Jae-Heon Kang, Kyung-Hee Park, Jong Ho Lee, Sang Ick Park, Jihyun Song
- Osong Public Health Res Perspect. 2014;5(5):251-257. Published online October 31, 2014
- DOI: https://doi.org/10.1016/j.phrp.2014.08.008
- 3,102 View
- 16 Download
- 8 Crossref
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Abstract
PDF - Objectives
Obesity in childhood increases the risk of obesity in adulthood, and is predictive of the development of metabolic disorders. The fatty acid compositions of various tissues, including blood, are associated with obesity and obesity-associated disorders. Thus, tracking plasma phospholipid (PL) features and metabolic parameters in young individuals may strengthen the utility of fatty acid composition as an early biomarker of future metabolic disorders.
Methods
Anthropometric and blood biochemical data were obtained from 131 Korean males aged 10.5 ± 0.4 years, and followed up at 2 years. We analyzed the plasma PL fatty acids according to obesity. Obese children were defined as those with a body mass index (BMI) greater than the 85th percentile for age and gender, based on Korean child growth standards.
Results
Activities of lipid desaturases, stearyl-CoAD (SCD-16,16:1n-7/16:0), delta-6D (D6D, 20:3n-6/18:2n-6), and delta-5D (D5D, 20:4n-6/20:3n-6), were estimated. Obese individuals had significantly higher proportions of palmitoleic acid (16:1n-7) and dihomo-gamma linolenic acid (DGLA, 20:3n-6) at both baseline and follow-up than did lean individuals. The activities of SCD-16 and D6D were higher in obese than lean boys. The baseline SCD-16 activity level was positively associated with the baseline waist circumference (WC) and the metabolic risk score. The baseline D6D level was positively associated with WC and also with the homeostasis model of assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance (IR), and metabolic risk score at both baseline and follow-up.
Conclusion
In young Korean males, higher D6D activity predicts the future development of IR and associated metabolic disorders including dyslipidemia. -
Citations
Citations to this article as recorded by
- Palmitoleic and Dihomo-γ-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children
Man-Chin Hua, Hui-Min Su, Ming-Wei Lai, Tsung-Chieh Yao, Ming-Han Tsai, Sui-Ling Liao, Shen-Hao Lai, Jing-Long Huang
Frontiers in Pediatrics.2021;[Epub] CrossRef - Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?
Camila O. de Souza, Gretchen K. Vannice, José C. Rosa Neto, Philip C. Calder
Molecular Nutrition & Food Research.2018;[Epub] CrossRef - Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children
Lori M. Beccarelli, Rachel Erin Scherr, John W. Newman, Alison G. Borkowska, Ira J. Gray, Jessica D. Linnell, Carl L. Keen, Heather M. Young
Journal of the American College of Nutrition.2018; 37(1): 44. CrossRef - Continuous cardiometabolic risk score definitions in early childhood: a scoping review
M. Kamel, B. T. Smith, G. Wahi, S. Carsley, C. S. Birken, L. N. Anderson
Obesity Reviews.2018; 19(12): 1688. CrossRef - FADS1-FADS2 gene cluster confers risk to polycystic ovary syndrome
Ye Tian, Wei Zhang, Shigang Zhao, Yinhua Sun, Yuehong Bian, Tailai Chen, Yanzhi Du, Jiangtao Zhang, Zhao Wang, Tao Huang, Yingqian Peng, Ping Yang, Han Zhao, Zi-Jiang Chen
Scientific Reports.2016;[Epub] CrossRef - Association of plasma fatty acid composition with plasma irisin levels in normal weight and overweight/obese children
A. Viitasalo, J. Ågren, T. Venäläinen, J. Pihlajamäki, J. Jääskeläinen, A. Korkmaz, M. Atalay, T. A. Lakka
Pediatric Obesity.2016; 11(4): 299. CrossRef - Linoleic acid and the pathogenesis of obesity
Shaan S. Naughton, Michael L. Mathai, Deanne H. Hryciw, Andrew J. McAinch
Prostaglandins & Other Lipid Mediators.2016; 125: 90. CrossRef - Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats
Venkatesh Gopalan, Navin Michael, Seigo Ishino, Swee Shean Lee, Adonsia Yating Yang, K. N. Bhanu Prakash, Jadegoud Yaligar, Suresh Anand Sadananthan, Manami Kaneko, Zhihong Zhou, Yoshinori Satomi, Megumi Hirayama, Hidenori Kamiguchi, Bin Zhu, Takashi Hori
Scientific Reports.2016;[Epub] CrossRef
- Palmitoleic and Dihomo-γ-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children
- Association Between Serum Vitamin D and Metabolic Risk Factors in Korean Schoolgirls
- Han Byul Jang, Hye-Ja Lee, Ju Yeon Park, Jae-Heon Kang, Jihyun Song
- Osong Public Health Res Perspect. 2013;4(4):179-186. Published online August 31, 2013
- DOI: https://doi.org/10.1016/j.phrp.2013.06.004
- 3,032 View
- 18 Download
- 15 Crossref
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Abstract
PDF
- Objectives
Vitamin D, a key regulator of bone metabolism, has been recently been linked with energy homeostasis and metabolic disorders in western countries. However, few studies have focused on the association of vitamin D with metabolic risk factors among Asian children. We studied the prevalence of vitamin D insufficiency and the association of 25-hydroxyvitamin D [25(OH)D] with metabolic risk factors in Korean schoolgirls.
Methods
The sample consisted of 320 13-year-old girls recruited from two middle schools in the city of Gwacheon, Korea (latitude 37°N), in July 2011. Anthropometric and blood biochemistry data were obtained for this cross-sectional observational study. We also obtained lifestyle data from questionnaires and dietary data from 3-day food diaries.
Results
Vitamin D deficiency [25(OH)D < 20 ng/mL] was noted in 63.8% of participants. The mean 25(OH)D level was not significantly lower in the overweight group. Level of physical activity and vitamin D intake did not significantly affect 25(OH)D. However, 25(OH)D levels were positively correlated with milk intake and negatively correlated with soft drink intake. Serum 25(OH)D had a negative relationship with fasting glucose and insulin resistance index (homeostasis model assessment-insulin resistance; HOMA-IR) after adjustment for physical activity and body mass index z score (r = −0.144, p = 0.015), and with metabolic risk score similarly (r = −0.141, p = 0.012). Levels of insulin, HOMA-IR, and systolic blood pressure were higher in girls with deficient 25(OH)D levels than in those with sufficient levels.
Conclusion
We found that low 25(OH)D levels were associated with higher blood glucose and insulin resistance. Korean girls with low 25(OH)D levels could be at increased risk for metabolic disorders. -
Citations
Citations to this article as recorded by- The Relationship Between Vitamin D Serum Levels and Metabolic Syndrome in Patients Referred to Central Laboratory of ACECR in Mashhad, Iran
Azam Shafaei, Zahra Saghiri, Mohammad Pahlavan Noghabi, Jalal Ghorbani, Arezoo Oroji, Fatemeh Sadabadi, Ahmad Vahedi, Maryam Shahi, Mahboobeh Talebi Mehrdar, Malihe Moammeri Salahshooh
Jentashapir Journal of Cellular and Molecular Biol.2022;[Epub] CrossRef - Vitamin D status and blood pressure in children and adolescents: a systematic review of observational studies
Myriam Abboud, Fatme Al Anouti, Dimitrios Papandreou, Rana Rizk, Nadine Mahboub, Suzan Haidar
Systematic Reviews.2021;[Epub] CrossRef - Relationship Between Vitamin D Status and the Relevant Parameters of Glucose in Patients with Type 2 Diabetes
Thanh Tung Tran Huu, Huu Dang Tran, Thua Nguyen Tran, Bui Bao Hoang
Diabetes, Metabolic Syndrome and Obesity: Targets .2021; Volume 14: 2489. CrossRef - Different Cabergoline Effect on Metabolic and Anthropometric Parameters in Female Prolactinoma Patients Versus Idiopathic Hyperprolactinemia Patients
Mohamed M. Aboelnaga, Eman H. Eladawy, Maha M. Elshafei, Nahed Abdullah, Moustafa El. Shaer
Endocrine, Metabolic & Immune Disorders - Drug Tar.2019; 19(4): 511. CrossRef - Seasonality of tuberculosis in the Republic of Korea, 2006-2016
Eun Hee Kim, Jong-Myon Bae
Epidemiology and Health.2018; 40: e2018051. CrossRef - Current Evidence on Vitamin D Deficiency and Metabolic Syndrome in Obese Children: What Does the Evidence from Saudi Arabia Tell Us?
Asma Alaklabi, Naser Alsharairi
Children.2018; 5(1): 11. CrossRef - The association between gender difference with metabolic syndrome, metabolic syndrome score and serum vitamin D levels in Korean adults
Hyun Yoon, Dae Keun Jeong, Chang Eun Park, Hye Jong Oh, Sung Gil Kim
International Journal of Food Sciences and Nutriti.2017; 68(1): 121. CrossRef - Serum 25-Hydroxyvitamin D associated with indicators of body fat and insulin resistance in prepubertal chilean children
G Cediel, C Corvalán, C Aguirre, D L de Romaña, R Uauy
International Journal of Obesity.2016; 40(1): 147. CrossRef - The relationship between metabolic syndrome and increase of metabolic syndrome score and serum vitamin D levels in Korean adults: 2012 Korean National Health and Nutrition Examination Survey
Hyun Yoon, Gwang Seok Kim, Sung Gil Kim, Ae Eun Moon
Journal of Clinical Biochemistry and Nutrition.2015; 57(1): 82. CrossRef - Vitamin D Deficiency and Cardiometabolic Risks: A Juxtaposition of Arab Adolescents and Adults
Nasser M. Al-Daghri, Yousef Al-Saleh, Naji Aljohani, Majed Alokail, Omar Al-Attas, Abdullah M. Alnaami, Shaun Sabico, Maha Alsulaimani, Mohammed Al-Harbi, Hanan Alfawaz, George P. Chrousos, Joseph Devaney
PLOS ONE.2015; 10(7): e0131315. CrossRef - Association of Serum 25-Hydroxyvitamin D with Life Style and Dietary Factors in Egyptian Prepubescent Children
Mones M. Abu Shady, Mai M. Youssef, Manal A. Shehata, Ebtissam M. Salah El-Din, Heba A. ElMalt
Open Access Macedonian Journal of Medical Sciences.2015; 3(1): 80. CrossRef - The Study of Serum Vitamin D and Insulin Resistance in Chinese Populations with Normal Glucose Tolerance
Lin Ding, Congcong Wang, Heliang Ma, Yuling Tian, Yong Lu, Shuguang Pang
International Journal of Endocrinology.2014; 2014: 1. CrossRef - Does Sufficient Evidence Exist to Support a Causal Association between Vitamin D Status and Cardiovascular Disease Risk? An Assessment Using Hill’s Criteria for Causality
Patricia Weyland, William Grant, Jill Howie-Esquivel
Nutrients.2014; 6(9): 3403. CrossRef - Vitamin D insufficiency and insulin resistance in obese adolescents
Catherine A. Peterson, Aneesh K. Tosh, Anthony M. Belenchia
Therapeutic Advances in Endocrinology and Metaboli.2014; 5(6): 166. CrossRef - Vitamin D Status among Thai School Children and the Association with 1,25-Dihydroxyvitamin D and Parathyroid Hormone Levels
Lisa A. Houghton, Andrew R. Gray, Michelle J. Harper, Pattanee Winichagoon, Tippawan Pongcharoen, Sueppong Gowachirapant, Rosalind S. Gibson, Dominique Heymann
PLoS ONE.2014; 9(8): e104825. CrossRef
- The Relationship Between Vitamin D Serum Levels and Metabolic Syndrome in Patients Referred to Central Laboratory of ACECR in Mashhad, Iran
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